Vitamin formulation

ABSTRACT

Solid particles comprising at least one fat-soluble vitamin are provided and exhibit better stability when compressed into tablets.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a continuation of U.S. Application Serial No.15/775,425 filed on May 11, 2018 (now U.S. Pat. No. XX,XXX,XXX), whichin turn is the U.S. national phase of International Application No.PCT/EP2016/080421 filed 9 Dec. 2016, which designated the U.S. andclaims priority to EP Patent Application No. 15199204.7 filed 10 Dec.2015, the entire contents of each of which are hereby incorporated byreference.

FIELD

The present patent application relates to solid particles comprising ahigh amount of at least one fat-soluble vitamin, which are more stablewhen compressed into tablets. Furthermore, the particles can be free ofany animal derived ingredient and therefore suitable for vegetarians.

BACKGROUND AND SUMMARY

Compressed tablets are a very useful way for administering fat-solublevitamins. They are easy to be consumed, easy to store and good tohandle.

When compressed tablets are produced, harsh conditions are to beapplied. It is clear that a certain pressure has to be used to compressany formulation into a tablet. Therefore, there is usually an issue,that the ingredients, which are part of the formulation, which is usedto be compressed, are squeezed out and therefore are not part of thetablet anymore. In other words, the tablet contains usually less of thefat-soluble vitamin in the compressed tablet than in the formulation,which was compressed. Usually the content of the fat-soluble vitamins isgetting less during the storage of the compressed tablets.

Gelatine, which is often used to formulate fat-soluble vitamins, isusually sourced from an animal source and therefore not suitable forvegetarians.

Due to the importance of compressed tablets, comprising fat-solublevitamins, there is always a need for improved compressible formulations.

Surprisingly it was found that such an improvement was achieved byadding one or more non-reducing sugar to the solid formulation, which isused to produce compressed tablets.

BRIEF DESCRIPTION OF THE DRAWINGS

FIGS. 1-3 are each graphs of the data in Tables 5-7, respectively, belowshowing vitamin A rentention (IU/g) versus days of storage.

DETAILED DESCRIPTION

The embodiments disclosed herein relate to solid particles (SP)comprising:

-   (i) at least 20 weight-% (wt-%), based on the total weight of the    solid particles, of least one fat soluble vitamin,-   (ii) at least one emulsifier, and-   (iii) at least one non-reducing sugar.

These solid particles show better storage stability (of the fat-solublevitamin) when compressed into tablets.

It also possible to produce solid particles with only these three kindof ingredients.

Therefore, the present invention relates to solid particles (SP’)consisting of

-   (i) at least 20 weight-% (wt-%), based on the total weight of the    solid particles, of least one fat soluble vitamin,-   (ii) at least one emulsifier, and-   (iii) at least one non-reducing sugar.

Preferred non-reducing sugars are non-reducing disaccharides; morepreferably sucrose and/or trehalose, most preferred is trehalose.

Sucrose is a disaccharide combination of the monosaccharides glucose andfructose with the formula C₁₂H₂₂O₁₁. It is commercially available frommany suppliers.

Sucrose is often extracted and refined from either cane or beet sugarfor human

Trehalose, also known as mycose or tremalose, is a natural alpha-linkeddisaccharide formed by an α,α-1,1-glucoside bond between two α-glucoseunits. There is an industrial process where trehalose is derived fromcorn starch. There are known biological pathways for trehalosebiosynthesis.

Trehalose is available commercially from various suppliers.

The amount of non-reducing sugar in the solid particles is from 5 - 55weight-% (wt- %), based on the total weight of the solid particles.Preferably 10 - 50 wt-%, based on the total weight of the solidparticles; more preferably 15 - 45 wt-%, based on the total weight ofthe solid particles.

Therefore the present invention relates to solid particles (SP1), whichare solid particles (SP) or (SP′) comprising 5 - 55 wt- %, based on thetotal weight of the solid particles, of at least one non-reducing sugar.

Therefore the present invention relates to solid particles (SP2), whichare solid particles (SP) or (SP’) comprising 10 - 50 wt- %, based on thetotal weight of the solid particles, of at least one non-reducing sugar.

Therefore the present invention relates to solid particles (SP3), whichare solid particles (SP) or (SP’) comprising 15 - 45 wt- %, based on thetotal weight of the solid particles, of at least one non-reducing sugar.

The solid particles according to the present invention comprise at leastone fat-soluble vitamin.

Fat-soluble vitamins are vitamin A, D, E, and K (as well as derivativesthereof). In a preferred embodiment of the present invention, vitamin Aand/or its derivatives (such as vitamin A acetate and vitamin Apalmitate) are used.

Therefore, the present invention relates to solid particles (SP4), whichare solid particles (SP), (SP’), (SP1) or (SP2), wherein the fat-solublevitamin is vitamin A and/or a derivative of vitamin A (especiallyvitamin A acetate or vitamin A palmitate).

The solid particles according to the present invention comprise usuallycomprise 20 - 75 wt-%, based on the total weight of the solid particles,of at least one fat soluble vitamin, preferably, 25 - 70 wt-%, based onthe total weight of the solid particles.

Therefore, the present invention relates to solid particles (SP5), whichare solid particles (SP), (SP’), (SP1), (SP2), (SP3) or (SP4), whereinthe solid particles comprise 20 - 75 wt-%, based on the total weight ofthe solid particles, of the fat-soluble vitamin(s).

Therefore, the present invention relates to solid particles (SP6), whichare solid particles (SP), (SP’), (SP1), (SP2), (SP3), (SP4) or (SP5),wherein the solid particles comprise 25- 70 wt-%, based on the totalweight of the solid particles, of the fat-soluble vitamin(s).

Furthermore, the solid particles according to the present inventioncomprise at least one emulsifier. Any commonly known and used emulsifiercan be used. A single emulsifier as well as a mixture of emulsifiers canbe used.

Suitable emulsifiers are modified (food) starches, ascorbyl palmitate,pectin, alginate, carrageenan, furcellaran, dextrin derivatives,celluloses and cellulose derivatives (e.g. cellulose acetate, methylcellulose, hydroxypropyl methyl cellulose), lignosulfonate,polysaccharide gums (such as gum acacia (= gum arabic), modified gumacacia, TIC gum, flaxseed gum, ghatti gum, tamarind gum andarabinogalactan), gelatine (bovine, fish, pork, poultry), plant proteins(such as are for example peas, soybeans, castor beans, cotton, potatoes,sweet potatoes, manioc, rapeseed, sunflowers, sesame, linseed,safflower, lentils, nuts, wheat, rice, maize, barley, rye, oats, lupinand sorghum), animal proteins including milk or whey proteins, lecithin,polyglycerol ester of fatty acids, monoglycerides of fatty acids,diglycerides of fatty acids, sorbitan ester, and sugar ester (as well asderivatives thereof).

Preferred are emulsifiers, which are not derived from an animal source.

More preferred emulsifiers are modified (food) starches, polysaccharidegums and plant proteins.

The starches can be modified physically and chemically. Pregelatinizedstarches are examples of physically modified starches. Acidic modified,oxidized, crosslinked, starch esters, starch ethers and cationicstarches are examples of chemically modified starches.

The amount of the emulsifier(s) in the solid particles is usually from20 - 70 wt-%, based on the total weight of the solid particles;preferably 25 - 65 wt-%, based on the total weight of the solidparticles.

Therefore the present invention relates to solid particles (SP7), whichare solid particles (SP), (SP’), (SP1), (SP2), (SP3), (SP4), (SP5) or(SP6), wherein the at least emulsifier is chosen from the groupconsisting of modified (food) starches, ascorbyl palmitate, pectin,alginate, carrageenan, furcellaran, dextrin derivatives, celluloses andcellulose derivatives (e.g. cellulose acetate, methyl cellulose,hydroxypropyl methyl cellulose), lignosulfonate, polysaccharide gums(such as gum acacia (= gum arabic), modified gum acacia, TIC gum,flaxseed gum, ghatti gum, tamarind gum and arabinogalactan), gelatine(bovine, fish, pork, poultry), plant proteins (such as are for examplepeas, soybeans, castor beans, cotton, potatoes, sweet potatoes, manioc,rapeseed, sunflowers, sesame, linseed, safflower, lentils, nuts, wheat,rice, maize, barley, rye, oats, lupin and sorghum), animal proteinsincluding milk or whey proteins, lecithin, polyglycerol ester of fattyacids, monoglycerides of fatty acids, diglycerides of fatty acids,sorbitan ester, and sugar ester (as well as derivatives thereof).

Therefore the present invention relates to solid particles (SP7′), whichare solid particles (SP), (SP’), (SP1), (SP2), (SP3), (SP4), (SP5) or(SP6), wherein the at least emulsifier is not derived from an animalsource.

Therefore the present invention relates to solid particles (SP7″), whichare solid particles (SP), (SP’), (SP1), (SP2), (SP3), (SP4), (SP5) or(SP6), wherein the at least emulsifier is chosen from the groupconsisting of modified (food) starches, polysaccharide gums and plantproteins.

Therefore the present invention relates to solid particles (SP8), whichare solid particles (SP), (SP’), (SP1), (SP2), (SP3), (SP4), (SP5),(SP6), (SP7), (SP7′) or (SP7″), wherein the amount of the emulsifier(s)in the solid particles is 20 - 70 wt-%, based on the total weight of thesolid particles.

Therefore the present invention relates to solid particles (SP9), whichare solid particles SP), (SP’), (SP1), (SP2), (SP3), (SP4), (SP5),(SP6), (SP7), (SP7′) or (SP7″), wherein the amount of the emulsifier(s)in the solid particles is 25 - 65 wt-%, based on the total weight of thesolid particles.

Furthermore, the solid particles can comprise further ingredients(auxiliary agents). Such auxiliary agents are for example antioxidants(such as ascorbic acid or salts thereof, tocopherol (synthetic ornatural)), butylated hydroxytoluene (BHT), ascorbyl palmitate, butylatedhydroxyanisole (BHA), propyl gallate, tert. butyl hydroxyquinoline,ethoxyquin and/or ascorbic acid esters of a fatty acid); stabilisers(such as gel-forming agents as xanthan gum, gellan gum); humectants(such as glycerine, sorbitol, polyethylene glycol); dyes; fragrances;fillers and buffers.

These auxiliary agents can be useful for the solid particles, for theirproduction, for the final product (for what the solid particles used)and/or for the production of the final product.

These compounds can optionally be used in an amount of up to 15 wt-%,based on the solid particles.

Therefore the present invention relates to solid particles (SP10), whichare solid particles (SP), (SP1), (SP2), (SP3), (SP4), (SP5), (SP6),(SP7), (SP7′), (SP7″), (SP8) or (SP9), comprising up to 15 wt-%, basedon the solid particles, of at least one auxiliary agents.

Therefore the present invention relates to solid particles (SP11), whichare solid particles (SP10), wherein the auxiliary agent (or auxiliaryagents) is chosen from the group consisting of antioxidants (such asascorbic acid or salts thereof, tocopherol (synthetic or natural)),butylated hydroxytoluene (BHT), ascorbyl palmitate, butylatedhydroxyanisole (BHA), propyl gallate, tert. butyl hydroxyquinoline,ethoxyquin and/or ascorbic acid esters of a fatty acid); stabilisers(such as gel-forming agents as xanthan gum, gellan gum); humectants(such as glycerine, sorbitol, polyethylene glycol); dyes; fragrances;fillers and buffers.

Depending on the way of the production of the solid particles accordingto the present invention it also possible that they are coated with apowder, which is used in the powder catch process. Such a powder can befor example corn starch.

The amount of the powder (especially of corn starch) can be up to 15wt-%, based on the total weight of the powder coated particles. Usuallythe content of the powder coating is kept as low as possible, so thatanother coating layer can be created.

Furthermore, it is also possible to coat the solid particles with acoating layer. This layer can be of any known and used coating material.

A suitable size of the solid particles of the present invention isbetween 50 -1000 µm (preferably 100 - 800 µm); the size is defined bythe diameter of the longest dimension of the particle and measured bycommonly known method (like laser diffraction)

All particle sizes of the solid particles according to the presentinvention are determined by laser diffraction technique using a“Mastersizer 3000” of Malvern Instruments Ltd., UK. Further informationon this particle size characterization method can e.g. be found in“Basic principles of particle size analytics”, Dr. Alan Rawle, MalvernInstruments Limited, Enigma Business Part, Grovewood Road, Malvern,Worcestershire, WR14 1XZ, UK and the “Manual of Malvern particle sizeanalyzer”. Particular reference is made to the user manual number MAN0096, Issue 1.0, November 1994. If nothing else is stated all particlesizes referring to the coarse particles of the solid particles accordingto the present invention are Dv90 values (volume diameter, 90% of thepopulation resides below this point, and 10% resides above this point)determined by laser diffraction. The particle size can be determined inthe dry form, i.e. as powder or in suspension. Preferably, the particlesize of the solid particles according to the present invention isdetermined as powder.

The distribution of the particle size of the solid particles is also noessential feature of the present invention.

The shape of the solid particles is also not an essential feature of thepresent invention. The shape can be sphere-like or any other form (alsomixtures of shapes). Usually and preferably, the particles aresphere-like.

The particles can be produced by any commonly known process, which areused to produce such particles (spray drying, spray chilling, etc.).

The process of coating such small particles is well known. It is usuallydone by fluidized bed spray granulation, film coating or wetgranulation.

The solid particles according to the present invention are mainly usedfor producing compressed tablet.

Therefore the present invention relates to the use of at least one solidparticle (SP), (SP′), (SP1), (SP2), (SP3), (SP4), (SP5), (SP6), (SP7),(SP7′), (SP7″), (SP8), (SP9), (SP10) and/or (SP11) in the production ofcompressed tablets.

The pressure, which is used to producing tablets, is at least 5 kN

The pressure, which is used to producing tablets, is usually between 5and 40 kN, preferably between 10 - 40 kN, more preferably between 5 - 40kN.

Therefore the present invention relates to the process (P) of producingcompressed tables wherein at least one solid particle (SP), (SP’),(SP1), (SP2), (SP3), (SP4), (SP5), (SP6), (SP7), (SP7′), (SP7″), (SP8),(SP9), (SP10) and/or (SP11) are compressed with at pressure of at least5 kN.

Therefore the present invention relates to the process (P′) of producingcompressed tables wherein at least one solid particle (SP), (SP’),(SP1), (SP2), (SP3), (SP4), (SP5), (SP6), (SP7), (SP7′), (SP7″), (SP8),(SP9), (SP10) and/or (SP11) are compressed with at pressure of between 5and 40kN,

Therefore the present invention relates to the process (P″) of producingcompressed tables wherein at least one solid particle (SP), (SP’),(SP1), (SP2), (SP3), (SP4), (SP5), (SP6), (SP7), (SP7′), (SP7″), (SP8),(SP9), (SP10) and/or (SP11) are compressed with at pressure of between10 - 40 kN.

Therefore the present invention relates to the process (P‴) of producingcompressed tables wherein at least one solid particle (SP), (SP’),(SP1), (SP2), (SP3), (SP4), (SP5), (SP6), (SP7), (SP7′), (SP7″), (SP8),(SP9), (SP10) and/or (SP11) are compressed with at pressure of between15 - 40 kN.

It is also possible to add any further ingredients (such as fillers,dyestuffs, antioxidants, flavours, etc.) to the solid particlesaccording to the present invention before compressing the particles intothe tablet.

Therefore the present invention relates to the process (P1), which isprocess (P), (P′), (P″) or (P‴), wherein at least one further ingredientis added.

The tablet can be a dietary supplement or a pharmaceutical product. Thisdepends what is added to the compressed tablets additionally.

Furthermore the present invention also relates to compressed tabletscomprising at least one solid particle (SP), (SP’), (SP1), (SP2), (SP3),(SP4), (SP5), (SP6), (SP7), (SP7′), (SP7″), (SP8), (SP9), (SP10) and/or(SP11).

The invention is illustrated by the following Example. All temperaturesare given in °C and all parts and percentages are related to the weight.

EXAMPLES Example 1: Food Modified Starch and Trehalose

370.6 g of deionized water were heated up to 60° C. - 65° C. in avessel. 316.75 g of food modified starch and 121.2 g of trehalose wereadded and the mixture was brought into solution while stirring at 60-65°C. The obtained solution was cooled to50- 55° C. and degassed for 1hour. Thereupon, 190.82 g of an oil mixture (180.78 g vitamin A acetate,5.02 g BHT and 5.02 g dl-alpha-tocopherol) were added to the matrixsystem and emulsified. The temperature of the process was always keptbelow 65° C. After emulsification the inner phase of the emulsion had anaverage particle size of about 272 nm (Dv(0.1 )=100 nm, Dv(0.5)=272 nm,Dv(0.9)=559 nm), measurement realized by laser diffraction (Malvern3000). After emulsification the moisture of the emulsion, determined bya halogen moisture analyzer (Mettler Toledo, Type HR73-P), was checkedand adapted if necessary. Afterwards 150 g of the emulsion were sprayedinto a spray pan containing 1500 g of corn starch using a rotating spraynozzle. The obtained particles were sieved off (150 to 600 µm) from theexcess of corn starch and dried at room temperature using a stream offair. The final product particle size after drying was in average 246 µm(Dv(0.1)= 198 µm, Dv(0.5) =246 µm, Dv(0.9) = 303 µm) measured by laserdiffraction (Malvern 3000).

Solid particles with the composition as listed in table 1 have beenobtained.

TABLE 1 Composition [wt%] Vit. A Ac. 2.8 Mio I.U/g 27.00dl-alpha-Tocopherol 0.75 BHT 0.75 Food modified starch 47.31 Trehalose18.19 Corn Starch 4.00 Water 2.00 Total 100.00

Example :2 Food Modified Starch and Trehalose

381 g of deionized water were heated up to 60° C. - 65° C. in a vessel.316.75 g of food modified starch and 122.2 g of trehalose were added andthe mixture was brought into solution while stirring at 60-65° C. Theobtained solution was cooled to 50-55° C. and degassed for 1 hour.Thereupon, 190.78 g of vitamin A acetate were added to the matrix systemand emulsified. The temperature of the process was always kept below 65°C. After emulsification the inner phase of the emulsion had an averageparticle size of about 333 nm (Dv(0.1 )=175 nm, Dv(0.5)=333 nm,Dv(0.9)=558 nm), measurement realized by laser diffraction (Malvern3000). After emulsification the moisture of the emulsion, determined bya halogen moisture analyzer (Mettler Toledo, Type HR73-P), was checkedand adapted if necessary. Afterwards 150 g of the emulsion were sprayedinto a spray pan containing 1500 g of corn starch using a rotating spraynozzle. The obtained particles were sieved off (150 to 600 µm) from theexcess of corn starch and dried at room temperature using a stream offair. The final product particle size after drying was in average 180 µm(Dv(0.1) =180 µm, Dv(0.5) =240 µm, Dv(0.9) = 321 µm) measured by laserdiffraction (Malvern 3000).

Solid particles with the composition as listed in table 21 have beenobtained.

TABLE 2 Composition [wt%] Vit. A Ac. 2.8 Mio I.U/g 27.00 Food modifiedstarch 48.31 Trehalose 18.19 Corn Starch 4.00 Water 2.00 Total 100.00

Example 3: Food Modified Starch and Sucrose

370.6 g of deionized water were heated up to 60° C. - 65° C. in avessel. 317.4 g of food modified starch and 122.1 g of sucrose wereadded and the mixture was brought into solution while stirring at 60-65°C. The obtained solution was cooled to 50-55° C. and degassed for 1hour. Thereupon, 197.3 g of an oil mixture (186.9 g vitamin A acetate,10.4 g BHT) were added to the matrix system and emulsified. Thetemperature of the process was always kept below 65° C. Afteremulsification the inner phase of the emulsion had an average particlesize of about 276 nm (Dv(0.1)=112 nm, Dv(0.5)=276 nm, Dv(0.9)=516 nm),measurement realized by laser diffraction (Malvern 3000). Afteremulsification the moisture of the emulsion, determined by a halogenmoisture analyzer (Mettler Toledo, Type HR73-P), was checked and adaptedif necessary. Afterwards 150 g of the emulsion were sprayed into a spraypan containing 1500 g of corn starch using a rotating spray nozzle. Theobtained particles were sieved off (150 to 600 µm) from the excess ofcorn starch and dried at room temperature using a stream off air. Thefinal product particle size after drying was in average 272 µm (Dv(0.1)=197 µm, Dv(0.5) =272 µm, Dv(0.9) = 377 µm) measured by laserdiffraction (Malvern 3000).

Solid particles with the composition as listed in Table 3 have beenobtained

TABLE 3 Composition [wt%] Vit. A Ac. 2.8 Mio I.U/g 27.00 BHT 1.50 Foodmodified starch 45.86 Sucrose 17.64 Corn Starch 5.00 Water 3.00 Total100.00

Example 4: Gum Acacia and Trehalose

381 g of deionized water were heated up to 60° C. - 65° C. in a vessel.143.78 g of food modified starch and 287.56 g of trehalose were addedand the mixture was brought into solution while stirring at 60-65° C.The obtained solution was cooled to 50-55° C. and degassed for 1 hour.Thereupon, 187.68 g of an oil mixture (177.80 g vitamin A acetate, 4.94g BHT and 4.94 g dl-alpha-tocopherol) were added to the matrix systemand emulsified. The temperature of the process was always kept below 65°C. After emulsification the inner phase of the emulsion had an averageparticle size of about 493 nm (Dv(0.1)=215 nm, Dv(0.5)=493 nm,Dv(0.9)=987 nm), measurement realized by laser diffraction (Malvern3000). After emulsification the moisture of the emulsion, determined bya halogen moisture analyzer (Mettler Toledo, Type HR73-P), was checkedand adapted if necessary. Afterwards 150 g of the emulsion were sprayedinto a spray pan containing 1500 g of cornstarch using a rotating spraynozzle. The obtained particles were sieved off (150 to 600 µm) from theexcess of corn starch and dried at room temperature using a stream offair. The final product particle size after drying was in average 234 µm(Dv(0.1) =189 µm, Dv(0.5) =234 µm, Dv(0.9) = 293 µm) measured by laserdiffraction (Malvern 3000).

Solid particles with the composition as listed in Table 4 have beenobtained.

TABLE 4 Composition [wt%] Vit. A Ac. 2.8 Mio I.U/g 27.00dl-alpha-Tocopherol 0.75 BHT 0.75 Gum acacia 21.83 Trehalose 43.67 CornStarch 4.00 Water 2.00 Total 100.00

Example 5: Stability in Stress Tablets

110.3 g of powder consisting of 27 g of vitamin A acetate particles (asobtained in Example 1), 33.24 g microcrystalline cellulose, 49.86 gcalcium phosphate and 0.2 g of magnesium stearate was mixed during 10min. This end preparation was then compressed with a pressure of 35 KN.The tablets (common disk-shaped; 0.2 g) were stored at room temperaturein a closed brown-glass bottle and the vitamin A acetate contentdetermined after 1, 7 and 35 days of storage.

For the purpose to show the superior property of the particles accordingto the present invention, comparative examples were also carried,wherein instead of trehalose or sucrose other sugars, which are nonon-reducing sugars, have been used. These comparative solid particleswere prepare as described in Example 1.

The impact of the use of trehalose is far better than other types ofplasticizer. This can be seen on the FIGS. 1, 2, and 3 . (in tables 5 -7, the solid particles are listed. The concentration of the ingredientsis the same as in Example 1).

TABLE 5 Compressed tablets as on FIG. 1 Graph Composition of the solidparticles 1 Vitamin A acetate Food modified starch Maltodextrin12BHT/toco 2 Vitamin A acetate Food modified starch trehalose BHT/toco 3Vitamin A acetate Food modified starch sucrose BHT/toco

TABLE 6 Compressed tablets as on FIG. 2 Graph Composition of the solidparticles 1 Vitamin A acetate Food modified starches Maltodextrin 20-23BHT/toco 2 Vitamin A acetate Food modified starches Maltodextrin 12BHT/toco 3 Vitamin A acetate Food modified starch trehalose BHT/toco

TABLE 7 Compressed tablets as on FIG. 3 Graph Composition of the solidparticles 1 Vitamin A acetate Gum acacia Maltodextrin 20-23 BHT/toco 2Vitamin A acetate Gum acacia Maltodextrin 12 BHT/toco 3 Vitamin Aacetate Gum acacia trehalose BHT/toco

1. Solid particles comprising: at least 20 wt-%, based on the totalweight of the solid particles, of least one fat soluble vitamin, atleast one emulsifier, and at least one non-reducing sugar.
 2. The solidparticles according to claim 1, wherein the at least one non-reducingsugar is present in an amount of 5-55 wt.%, based on the total weight ofthe solid particles, of at least one non-reducing sugar.
 3. The solidparticles according to claim 1, wherein the at least one reducing sugarcomprises trehalose.
 4. The solid particles according to claim 2,wherein the at least one non-reducing sugar is present in an amount of10 - 50 wt.%, based on the total weight of the solid particles.
 5. Thesolid particles according to claim 1, wherein the fat soluble vitamin isvitamin A and/or derivatives thereof.
 6. The solid particles accordingto claim 5, wherein the fat soluble vitamin is selected from the groupconsisting of vitamin A acetate and vitamin A palmitate.
 7. The solidparticles according to claim 1, wherein the at least one fat-solublevitamin is present in an amount of 20 - 75 wt.%, based on the totalweight of the solid particles.
 8. The solid particles according to 7,wherein the at least one fat-soluble vitamin is present in an amount of20 - 70 wt.%, based on the total weight of the solid particles.
 9. Thesolid particles according to claim 1, wherein the at least oneemulsifier is present in an amount of 20 - 70 wt.%, based on the totalweight of the solid particles.
 10. The solid particles according toclaim 1, wherein the at least emulsifier is selected from the groupconsisting of modified food starch and gum acacia.
 11. The solidparticles according to claim 1, wherein the solid particles have a size(Dv90) between 50-1000 µm.
 12. The solid particles according to claim 1,wherein the solid particles have a size (Dv90) between 100-800 µm.
 13. Acompressed tablet comprising the solid particles according to claim 1.14. The compressed tablet according to claim 13, wherein the solidparticles comprise: (i) at least 20 wt.%, based on the total weight ofthe solid particles, of least one fat soluble vitamin selected from thegroup consisting of vitamin A, vitamin A acetate and vitamin Apalmitate, (ii) 20 - 70 wt.%, based on the total weight of the solidparticles, of at least one emulsifier selected from the group consistingof modified food starch and gum acacia, and (iii) 5 - 55 wt.%, based onthe total weight of the solid particles, of trehalose as a non-reducingsugar.
 15. The compressed tablet according to claim 14, wherein thetrehalose is present in an amount of 10 - 50 wt.%, based on the totalweight of the solid particles.
 16. The compressed tablet according toclaim 14, wherein the at least one fat-soluble vitamin is present in anamount of 20 - 75 wt.%, based on the total weight of the solidparticles.
 17. The compressed tablet according to claim 14, wherein theat least one fat-soluble vitamin is present in an amount of 25 - 70wt.%, based on the total weight of the solid particles.
 18. Thecompressed tablet according to claim 14, wherein the solid particleshave a size (Dv90) between 50-1000 µm.
 19. The compressed tableaccording to claim 14, wherein the solid particles have a size (Dv90)between 100-800 µm.
 20. A method of forming a compressed tabletcomprising subjecting the solid particles according to claim 1 to apressure of at least 5 kN to thereby form the compressed tabletcomprised of the solid particles.
 21. The method according to claim 20,wherein the compression pressure is between 5 and 40 kN.